I'd always heard that odd-numbered US highways travel primarily north-south. The start of Highway 101, some 1,500 miles away in Olympia, WA, certainly appears to be almost due north of the end in Los Angeles.
But there's always The Valley.
In the San Fernando Valley through Southern California, the 101 cuts directly east-west. In the Valley, when you cross the 101, you are traveling north-south. There is no east of the 101. There is no west of the 101.
Then the 101 cuts an angle - northwest-southeast - across the Hollywood Hills through Hollywood and downtown LA.
Hollywood's major surface streets cross the 101 from east to west. So if I come from Atwater Village in east LA, and I get on Hollywood Blvd., Sunset Blvd., or Santa Monica Blvd., I'm traveling west across the 101.
But why would I want to do that?
(Kidding. I know the ocean is west.)